Minggu, 29 Desember 2013

[C577.Ebook] Free Ebook The Politics of Postmodernism (New Accents), by Linda Hutcheon

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The Politics of Postmodernism (New Accents), by Linda Hutcheon

This classic text remains one of the clearest and most incisive introductions to postmodernism. Perhaps more importantly, it is a compelling discussion of why postmodernism matters. Working through the issue of representation in art forms from fiction to photography, Linda Hutcheon sets out postmodernism's highly political challenge to the dominant ideologies of the western world. A new epilogue traces the fate of the postmodern over the last ten years and into the future, responding to claims that it has, once and for all, 'failed'.
Together with the new epilogue, this edition contains revised notes on further reading and a fully updated bibliography. This revised edition of The Politics of Postmodernism continues its position as essential reading.

  • Sales Rank: #1488310 in Books
  • Published on: 2002-06-30
  • Released on: 2002-05-16
  • Original language: English
  • Number of items: 1
  • Dimensions: 7.79" h x .53" w x 5.08" l, .57 pounds
  • Binding: Paperback
  • 232 pages

Review
"Intelligent and well-informed, Hutcheon's book (which also supplies the reader with a generous bibliography), in its reference to a multitude of verbal and visual texts as well as critical writings on the subject, is an excellent text for pedagogical purposes." -- Novel

About the Author
Linda Hutcheon is Professor of English and Comparative Literature at the University of Toronto. She has published extensively on postmodernism, parody and irony (including Irony's Edge: The Theory and Politics of Irony) and has recently done interdisciplinary work with Michael Hutcheon on opera and medicine (Opera: Desire, Disease and Death, and Bodily Charm: Living Opera).

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Jumat, 20 Desember 2013

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Accounting Information Systems: The Processes and Controls

Accounting Information Systems by Turner, Leslie, Weickgenannt, Andrea. . Wiley, 2013 2nd edition.

  • Sales Rank: #4163430 in Books
  • Binding: Hardcover

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Selasa, 17 Desember 2013

[O263.Ebook] Free PDF Houses on the Edge, by Alejandro Bahamon

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Houses on the Edge, by Alejandro Bahamon

To build a house -- a livable, workable, practical house -- in inhospitable environments is among the most ambitious projects an architect can undertake. Houses on the Edge features 28 homes from around the world built on mountainsides, cliff faces, and other such spaces -- ll of which combine remarkable site control with cutting edge architecture to create truly spectacular examples of residential architecture with exquisite views, exceptional privacy, and incredible technical and artistic achievement. Truly, these are among the world's most inspiring houses.

  • Sales Rank: #2307171 in Books
  • Published on: 2003-12-23
  • Released on: 2003-12-23
  • Original language: English
  • Number of items: 1
  • Dimensions: 10.72" h x .73" w x 9.78" l, 2.59 pounds
  • Binding: Hardcover
  • 176 pages

About the Author

Alejandro Baham�n is an architect, writer, and editor. He is the author of many design and architecture books including Mini House, Small Apartments, and Small Lofts.

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0 of 0 people found the following review helpful.
Interesting projects but seemingly overrated
By Adam Pfeifer
I like this book. It has a lot of good projects in it for reference, but there are several photos and drawings that have been scaled way past their acceptable viewing rates making the drawings/ photos pixelated and illegible. I also wish there was more description about some of the houses - the way they countered the slope of the site, to include structural/ foundation information. Beyond that, a good book for inspiration.

0 of 0 people found the following review helpful.
Five Stars
By Tengo
great book for architects

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Jumat, 13 Desember 2013

[A644.Ebook] PDF Download Prion Biology (Perspectives CSHL)From Cold Spring Harbor Laboratory Press

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Prions are best known as the agents of mad cow and related diseases, and a growing number of proteins with prion-like properties have been implicated in diseases such as Parkinson's. But some recently discovered prion-like proteins do not appear to induce pathological changes and, in fact, may be key players in basic biological processes such as transcription, immune regulation, and memory formation.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the expanding roles of prions and prion-like proteins in health and disease. The contributors review the structures of prions and prion-like proteins, how they aggregate into amyloid fibrils and other insoluble complexes, and the unique biological properties of the aggregated forms (e.g., infectivity, gain/loss of function, and self-templating). The normal physiological roles of prion-like proteins (e.g., CPEB in the brain and MAVS in the immune response) are discussed, as is the formation of abnormal protein aggregates via prion-like mechanisms in various human diseases.

The authors also discuss prions in yeast and other fungi, which are convenient models for studying mechanisms of amyloid formation and propagation. This volume is therefore an essential reference for biochemists, cell and molecular biologists, and all who wish to understand how these alternatively folded, self-propagating proteins function.

  • Sales Rank: #854984 in Books
  • Published on: 2017-08-31
  • Original language: English
  • Number of items: 1
  • Dimensions: .0" h x .0" w x .0" l, .0 pounds
  • Binding: Hardcover
  • 456 pages

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Rabu, 11 Desember 2013

[W521.Ebook] Free Ebook Adnan's Story, by RABIA CHAUDRY

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Now a New York Times bestseller

A Washington Post notable nonfiction book for 2016

A Goodreads Best of 2016 Nonfiction Finalist

A Kobo Best Book of 2016

Includes an update from Rabia on Adnan's vacated murder conviction in summer 2016

Serial only told part of the story…

In early 2000, Adnan Syed was convicted and sentenced to life plus thirty years for the murder of his ex-girlfriend Hae Min Lee, a high school senior in Baltimore, Maryland. Syed has maintained his innocence, and Rabia Chaudry, a family friend, has always believed him. By 2013, after almost all appeals had been exhausted, Rabia contacted Sarah Koenig, a producer at This American Life, in hopes of finding a journalist who could shed light on Adnan’s story. In 2014, Koenig's investigation turned into Serial, a Peabody Award-winning podcast with more than 500 million international listeners

But Serial did not tell the whole story. In this compelling narrative, Rabia Chaudry presents new key evidence that she maintains dismantles the State's case: a potential new suspect, forensics indicating Hae was killed and kept somewhere for almost half a day, and documentation withheld by the State that destroys the cell phone evidence -- among many other points -- and she shows how fans of Serial joined a crowd-sourced investigation into a case riddled with errors and strange twists. Adnan's Story also shares Adnan’s life in prison, and weaves in his personal reflections, including never-before-seen letters. Chaudry, who is committed to exonerating Adnan, makes it clear that justice is yet to be achieved in this much examined case.

  • Sales Rank: #1096321 in Books
  • Brand: imusti
  • Published on: 2016
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.21" h x 1.14" w x 6.02" l, .0 pounds
  • Binding: Paperback
Features
  • Random House Export Editions

Review

"If you're looking to revisit the story of Adnan Syed that enthralled millions of listeners for the first season of "Serial," look no further than this book from Rabia Chaudry, a friend of the Syed family who first brought the case to "Serial" host Sarah Koenig's attention." ―RedEye

"True crime enthusiasts and anyone willing to delve into the unsettling world of guilt versus innocence will find Adnan’s Story an enjoyable, but heart-wrenching ride. Chaudry has an impressive command of style–using the perfect balance of compassion and investigation to open Syed’s case to the world." ―The Lineup

"Rabia put her heart and soul [into this]. This isSerial come to life. If you liked the podcast, you will love this book." ―Daisy Khan, WISE

“Chaudry's book is essential reading for anyone who wants to understand how media ― particularly social media ― came to play such a powerful role in this case . . . Chaudry's passion clearly drives Adnan's Story: The Search for Truth and Justice After 'Serial.' But it's the mix of media skills and legal education that makes her book such an illuminating firsthand report from the front lines of social media change.” ―Baltimore Sun

“Chaudry’s clear, vivid and highly readable account of the case will bring the story to life for readers unfamiliar with the podcast, and even the most devoted 'Serial' fans will find fresh insight and a vast amount of new material. Chaudry’s legal training serves her well as she marshals her defense, but so too does the Pakistani heritage and Muslim faith she shares with Syed.” ―Washington Post

“Crisp, powerful prose...Chaudry’s description of the PCR hearing in Adnan’s Story is utterly riveting―high stakes, a breakneck pace, brilliant expert witnesses.” ―Entertainment Weekly

"Any 'Serial' fan should eat up this heavily researched book." ―New York Post

"Rabia Chaudry is a woman on a mission . . . It was easy to forget, listening to 'Serial,' that it was a true story about real people. Adnan's Story adds context and humanizes it in a way that could change how you think about the case, and about 'Serial' itself." ―Los Angeles Times

“Adnan's Story should satisfy those who can’t get enough of this perplexing case.”―Newsday

"You’ll find yourself tearing through the book as quickly as you binged on episodes of the podcasts." ―Bustle

"Lays out new details that [Chaudry] believes exonerate Syed...[they] already have produced results." ―People

"As stories of wrongful convictions go, Adnan’s Story is hands down a certain winner." ―New York Journal of Books

"Chaudry is uniquely qualified to tell this story." ―Elle.com

"A skillfully written account of injustice that will have wide appeal to fans of Serial and readers of human interest stories, and is especially timely as Syed's conviction was vacated in July 2016 and a new trial granted." ―Library Journal

"Readers new to the story will have no trouble following―the narrative is outlined extensively from the beginning―and podcast listeners will find plenty of previously undisclosed material...She strongly makes the case for cultural and religious bias in the investigation and conviction and presents damaging evidence of police misconduct, including tampering with evidence and a witness. She also examines other suspects and their possible motives and alibis." ―Publisher's Weekly, starred review

"A page-turner...[Chaudry's] writing is clear, eloquent, and engaging, and her case is convincing." ―Kirkus, Starred review

"Chaudry includes a great deal of important information that was never dealt with in either podcast, Serial or Undisclosed...The rich information provided elegantly by Chaudry helps the reader construct the world in which Adnan Syed, his family and friends live." ―TAPinto

About the Author
RABIA CHAUDRY is an attorney, a senior fellow at the U.S. Institute of Peace, and a national security fellow at the New America Foundation. She is the co-host of Undisclosed, one of the top-ranked podcasts in the iTunes store. She is a frequent public speaker, and her writing has appeared in numerous outlets including Time.com, The Huffington Post, and the Chicago Sun-Times.

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39 of 40 people found the following review helpful.
Read the book, not on a Kindle
By CDin
I really enjoyed the book. Prior to reading the book, I had only heard the Serial podcast. My only complaint is that I read it on my Kindle. The author, Rabia Chaudry, inserted copies of notes, hearing transcripts, etc. I could not read them on the kindle because the print was too small. It would not enlarge.

I pretty much figured out what the contents were, but it would have been nice to be able to read it (or have a transcript written below).

11 of 11 people found the following review helpful.
I highly recommend this book even after listening to all of the podcasts about Adnan.
By Lori Nees
Wonderful read with even more insight than the podcasts. Rabia did a great job explaining all of the history in an easy to follow read.

8 of 9 people found the following review helpful.
Fearless, captivating, page-turning, gut-wrenching
By Tazeen Qudsi
Is there a word stronger than love..? I've been following the case since late last year. I was a late bloomer in the serial world. But I listened to almost all episodes of undisclosed as well. When I got this book I didn't expect too much new info. I expected more of the same. But for the first time in my life, I was wrong. Not only did I find a lot of very interesting new information, but I also found a new hero: Rabia. The best way I can describe her is a very well educated, thorough and eloquent bada$$. Her writing style is captivating and I found myself laughing to tears at some points, clenching my pillow with anticipation at others. She creates the scene so well and takes the reader through a time machine to land directly in the moment. She captured Adnan's story so well, I feel most readers, like myself, feel like we've known him for years by the end of this book. Beyond that she did a great job of setting the scene, and explaining the community of ISB. The muslim culture is sorely misrepresented and misunderstood on a large scale. I grew up going to Sunday school at ISB, and while I wasn't too involved in the community I was surrounded by it. This book, Rabia, does a great job of depicting what life was like for the most common Muslim American teens. The same lifestyle that was painted over with a broad and very bigoted brush at this trial. This book is Adnans story, but his story the embodiment of everything that Muslim Americans right now fear. Her fearless and outspoken nature shine brightly through the pages of this work, and we need more outspoken and dedicated individuals like Rabia in our community and world. Can't wait to read her next work!

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Selasa, 10 Desember 2013

[M278.Ebook] Get Free Ebook The Structure of Science: Problems in the Logic of Scientific Explanation (2nd edition), by Ernest Nagel

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The Structure of Science: Problems in the Logic of Scientific Explanation (2nd edition), by Ernest Nagel

The Structure of Science: Problems in the Logic of Scientific Explanation (2nd edition), by Ernest Nagel



The Structure of Science: Problems in the Logic of Scientific Explanation (2nd edition), by Ernest Nagel

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The Structure of Science: Problems in the Logic of Scientific Explanation (2nd edition), by Ernest Nagel

"Ernest Nagel's work, The Structure of Science, has earned for itself the status of an outstanding standard work in its field. It offers an exceptionally thorough and comprehensive methodological and philosophical exploration encountered in those diverse fields. Nagel's discussion is distinguished by the lucidity of its style, the incisiveness of its reasoning, and the solidity of its grounding in all the major branches of scientific inquiry. The Structure of Science has become a highly influential work that is widely invoked in the methodological and philosophical literature. Recent controversies between analytics and historic-sociological approaches to the philosophy of science have not diminished its significance; in fact, it seems to me that the pragmatist component in Nagel's thinking may be helpful for efforts to develop a rapprochement between the contending schools." --Carl G. Hempel

  • Sales Rank: #1087437 in Books
  • Brand: Brand: Hackett Pub Co
  • Published on: 1979-06-01
  • Original language: English
  • Number of items: 1
  • Dimensions: 1.33" h x 5.52" w x 8.60" l, 1.55 pounds
  • Binding: Paperback
  • 618 pages
Features
  • Used Book in Good Condition

Review
Ernest Nagel's work, The Structure of Science , has earned for itself the status of an outstanding standard work in its field. It offers an exceptionally thorough and comprehensive methodological and philosophical exploration encountered in those diverse fields. Nagel's discussion is distinguished by the lucidity of its style, the incisiveness of its reasoning, and the solidity of its grounding in all the major branches of scientific inquiry. The Structure of Science has become a highly influential work that is widely invoked in the methodological and philosophical literature. Recent controversies between analytics and historic-sociological approaches to the philosophy of science have not diminished its significance; in fact, it seems to me that the pragmatist component in Nagel's thinking may be helpful for efforts to develop a rapprochement between the contending schools. --Carl G. Hempel

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26 of 31 people found the following review helpful.
The Documentation of the Nature of Science
By Scholastic Reader
There's lots of talk over what "science" really is and what constitutes "scienticity". Despite the fact that the word science comes from the Latin word "scientia" (literally meaning "knowledge"), it seems many have idealized or reified versions of it in mind, not a realistic version. Some seem to blindly and ignorantly assume that science is "empirical" or "conclusive" or "objective" or "strictly observationally based" or "skeptical" or "exclusively inductive" or "not deductive" other simplified maxims popularized by popular science magazines, books, and channels [National Geographic, Discovery, Scientific American, etc]. Research journals and academic writings, on the other hand, generally show more realistic complexities that are common among scientists and science. In reality, science really is all over the place and cannot be purged of emotions, humanity, or bias. Basic things people do inevitably play key roles in science like inquiry, thought, and reasoning as the basis of investigations of nature. These are also the basis for investigating local events, picking a car insurance wisely, managing ones own money, and solving personal problems. This work describes with heavy detail the very "nature" of science and Ernest Nagel does a phenomenal job of putting science where it belongs implicitly - as philosophy. Not only that but the fact that he includes discourse on the social sciences is worth getting the book. Many times when people or the media talk about science they seem to ignore or downplay the social sciences as if they were not sciences or treat them as weak/soft sciences. This is erroneous in my view as even ideas like natural selection were partially derived or inspired from the social sciences (Wallace and Darwin acknowledged inspiration from Thomas Malthus' work on human populations in their writings, for instance).

"Natural Philosophy" was the common name of what we call "science", up to the 19th century. For example, Newton's famous 17th century work was called "Mathematical Principles of Natural Philosophy". In the 19th century, Lord Kelvin's text in Physics was called "Treatise on Natural Philosophy". Interestingly, the term "scientist" emerged in 1834, not before, by William Whewell who was an Anglican priest and naturalist. Before this, it was very common for people who studied nature to be called "Natural Philosopher". The 'Structure of Science' does a good job of making the distinction that science is not nature and that nature is not science. The study and attempt of simulation of nature is what leads to any science, whether it be a superstitious science, statistical science, an abstract science, a true science, or a false science. For a general history of "Natural Philosophy" one can check out A History of Natural Philosophy: From the Ancient World to the Nineteenth Century.

Indeed, the philosophical nature of science is seen in the highest title of nearly every scientific field - "Ph.D". It stands for "Doctor of Philosophy". Also in science media, philosophers of science like Karl Popper or Thomas Khun are used and referenced perpetually to define what "is" and what "is not" science (aka the Demarcation Problem), not scientists per se. The fact that today most scientists have very narrow and specialized training in very few fields in the sciences (Simonton, Dean. "Scientific genius is extinct". Nature. January 2013 493(7434):602), not the whole enterprise of the sciences, means that most scientists would normally not be aware of research or methodology across disciplines and limits their knowledge of how research is done on most other fields. Understanding very few parts does not necessarily mean an understanding of the whole. Each field has its limits and degrees of precision within the context of the topics that are studied. Physicists do not focus much on biological issues for instance and vice versa. Perhaps this is why philosophers, and historians too, have become the go-to people for much of the modern discourse of what makes science. Philosophers of science and historians of science tend to traverse through many disciplines and get a general sense of science in many fields as opposed to a few. For instance, this book surveys science from diverse major disciplines (mathematics, physics, chemistry, biology, social sciences, etc).

Empiricism and physical evidence do constitute a decent chunk of "science", but overall, after reading the book one will notice more that metaphysical aspects like: imagination, creativity, experimental and general methodologies, knowledge, understanding, ideas, thinking, reasoning, verification, clarification, assumption, inquiring (what, when, where, how, why), explanation, validation, prediction, modeling, numerical analysis, truth seeking, theories, mathematical rigor, basic common logic, laws, models, good faith, and "certainty"; and serendipity (see The Travels and Adventures of Serendipity: A Study in Sociological Semantics and the Sociology of Science) make up the vast majority of what is called "science". We all gather information from nature all the time (empirical data), but it's what we do with the gathered information that makes up science. I know that some people think that science and philosophy are different, but the evidence speaks volumes to the contrary and the history of science testifies to this very well. For an excellent resource that uses position documents from scientific organizations like AAAS, National Science Foundation, and National Academy of Sciences on what science is and its foundations one can check out Scientific Method in Brief. It provides one of the best discussions on the scientific method in practice today.

Note: The words "Nature", "Science", and "Technology" are not the same thing and should NOT be used interchangeably due to their separate spheres of occurrence: what physically exists (Nature), assumption and modeling (Science), and application of and enhancement of science (Technology).

I will write the Chapter titles and give some objects of discussion found in these chapters.

1. "Introduction: Science and Common Sense"
What makes science different from common sense, specificity of systematic explanations, the rise of science from practical advantages, systematic configuration of information, specificity of "scientific" languages as explanations of explanations

2. "Patterns of Scientific Explanation"
The place of the explandum in statements of explanations for "why" questions, illustrations of scientific explanation, 4 types of explanation (with corresponding problems in their usage as explanations): Deductive Model of Explanation, Probabilistic Explanations, Teleological or "Functional" Explanations, and Genetic Explanations. Lack of explanations for the "necessity" of the ontology of natural phenomena

3. "The Deductive Pattern of Explanation"
Problems and insights explanation, applications of explanations on the conformity of natural laws, explanations applied on individual events, common emergence of generality found in explanations, epistemic requirements for Deductive Explanation including the Aristotelian view of appropriate adequacy for premises in Deductive Explanation

4. "The Logical Character of Scientific Laws"
Accidental and Nomic universality, difficulties of arguing of laws as necessary constructs of reality, the nature of nomic universality, contrary-to-fact universals, critiques of Hume's nomic universality, causal laws, locus of inference; multiple historical examples emphasizing the significance of these issues

5. "Experimental Laws and Theories"
Distinctions between experimental laws and theories, descriptions as non-logical constructs in experimental laws, the 3 major components of theories (Physical and Chemical mostly): 1. abstract calculus, 2. rules that reference empirical content, and 3. interpretation that unites the abstractions and references; Lack of direct empirical evidence for many aspects of theories, vagueness of some theoretical language

6. "The Cognitive Status of Theories"
Analogy as basis for theories, "Descriptive" view of theories; translatability, or lack thereof, of theoretical languages among theories and other theories, "Instrumentalist" view of theories, abstractive and hypothetical theories, theories based on "Ideal" conditions, parameters, and shapes

7. "Mechanical Explanations and the Science of Mechanics"
What a Mechanical Explanation is, the history of Mechanics - Statics and Dynamics, detailed discussion over Newton's 3 Laws of Motion and their significance, limits of using mathematics for deriving laws, ideal state problems as a guide to Mechanics, the logical status of mechanical science

8. "Space and Geometry"
Classical Mechanics and Euclidean (pure) Geometry

9. "Geometry and Physics"
Inadequacy of Classical Mechanics and the rise of Relativity and 2 Non-Eucladian Geometries: 1. Lobachewskian Geometry and 2. Reimannian Geometry

10. "Causality and Indeterminism in Physical Theory"
Deterministic structure of Classical Mechanics, alternate descriptions of physical states, atomic statistically properties of substances, lack of empirical evidence for components of statistical hypotheses, Probabilistic Explanations, language of Quantum Mechanics, Heisenberg's Uncertainty Principle, problems and misinterpretations of uncertainties, dual nature subatomic constructs, Psi functions as statistical magnitude measurements, indeterminism in Quantum Theory, principle of causality, Chance as meaning scientific ignorance

11. "Reduction of Theories"
Autonomy of sciences, reduction of sciences, reductive explanations, reduction of the thermodynamics to statistical mechanics, formal conditions for reduction, non-formal conditions for reduction, borrowing of theories and laws by other sciences, doctrine of emergence, possible changing of laws of nature, wholes, sums, and organic unities

12. "Mechanical Explanations and Organismic Biology"
Objections to Biology being absorbed or reduced to Physics, structure of Teleological Explanations, "design" or "functional" language almost impossible to avoid in biological and physiological systems (some examples I have heard of are God-of-the-Gaps fallacy and the Evolution/Chance-of-the-Gaps fallacy), spatial and temporal organization statements as implying a "final end or purpose", standpoint of organismic biology, reduction and "primary sciences" and "secondary sciences", lack of complete autonomy of Biology as of yet

13. "Methodological Problems of the Social Sciences"
Objections to social sciences (Anthropology, Social Science, Political Science, Economics, Psychology, etc) as being true "sciences", controlled inquiry as a core method, difficulties in controlled experiments, problems with social relativity and social laws, bias, knowledge of social phenomenon as social variables, subjective nature of social subject matter, "behaviorism", "value-oriented" bias of social inquiry

14. "Explanation and Understanding of the Social Sciences"
Statistical generalizations, "functionalism" and teleological and causal explanations, methodical individualism and social interpretations

15. "Problems in the Logic of Historical Inquiry"
Reliability of sources, the focus of historical inquiry, Probabilistic and Genetic Explanations, recurrent issues in historical inquiry, and Determinism in history (read Historians' Fallacies: Toward a Logic of Historical Thought for an excellent look at fallacies in the science of history)

This book is 600 pages of rigor and is very dense in content. A prior background in Physics or Chemistry and Calculus will be helpful. I think that this book is better than Popper's works and that this book deserves a wide audience. After reading this and the Christian lawyer Francis Bacon's The New Organon and Related Writings which is to be the foundational text on the modern "Scientific Method" and it's variants, you will know what science truly is.

Nature doesn't advance because nature simply "does" what it can do without thinking or purpose in and of itself. However, science (a.k.a. knowledge), on the other hand, does and can advance because of our own ignorance and failures in our knowledge and understanding of the activities in nature.

For those who are interested in the variant views of nature and naturalism among scientists and other scholars one can check out The Nature of Nature: Examining the Role of Naturalism in Science.

For further reading on types of explanations used in science and also in every day life then please read Theories of Explanation. For further reading on similar issues please read The Structure of Scientific Theories. You'll see that science isn't anything special, but is instead commonly used by the uneducated as well. Since science involves design inevitably, a good summary of universal design principles (modeling, prototyping, chunking information, hierarchies of ideas, etc.) can be found in Systems Engineering and Analysis (5th Edition) (Prentice Hall International Series in Industrial & Systems Engineering) and also Universal Principles of Design, Revised and Updated: 125 Ways to Enhance Usability, Influence Perception, Increase Appeal, Make Better Design Decisions, and Teach through Design.

-----------------------
Interesting issues in recent research: some studies have investigated the assumption of "self-correction" in the sciences. (John Ioannidis. "Why Science Is Not Necessarily Self-Correcting." Perspectives on Psychological Science. November 2012 7: 645-654 ; Stroebe, Postmes, Spears. "Scientific Misconduct and the Myth of Self-Correction in Science". Perspectives on Psychological Science. November 2012 7: 670-688 ; Jennifer Couzin-Frankel. "Secretive and Subjective, Peer Review Proves Resistant to Study". Science. September 2013 341(6152):1331). They are worth looking into.

Interesting fact: Most historical works in science never went through a "peer review" process at all by "impartial" referees. Usually friends or personal peers would comment and review. After World War II, peer reviewing by "impartial" peers before publishing became the norm.

Read Frank Tipler's paper "Refereed Journals: Do They Insure Quality or Enforce Orthodoxy?" for further information on this aspect of modern science. Here are a few sample quotes:

"We first need to understand what the "peer review" process is. That is, we need to understand how the process operates in theory, how it operates in practice, what it is intended to accomplish, and what it actually does accomplish in practice. Also of importance is its history. The notion that a scientific idea cannot be considered intellectually respectable until it has first appeared in a "peer" reviewed journal did not become widespread until after World War II. Copernicus's heliocentric system, Galileo's mechanics, Newton's grand synthesis--these ideas never appeared first in journal articles. They appeared first in books, reviewed prior to publication only by the authors or by the authors' friends. Even Darwin never submitted his idea of evolution driven by natural selection to a journal to be judged by "impartial" referees. Darwinism indeed first appeared in a journal, but one under the control of Darwin's friends. And Darwin's article was completely ignored. Instead, Darwin made his ideas known to his peers and to the world at large through a popular book: On the Origin of Species."

"If one reads memoirs or biographies of physicists who made their great breakthroughs after, say, 1950, one is struck by how often one reads that "the referees rejected for publication the paper that later won me the Nobel Prize." One example is Rosalyn Yalow, who described how her Nobel-prize-winning paper was received by the journals. "In 1955 we submitted the paper to Science[the Journal]. The paper was held there for eight months before it was reviewed. It was finally rejected. We submitted it to the Journal of Clinical Investigations, which also rejected it." (Quoted from The Joys of Research, edited by Walter Shropshire, p. 109). Another example is G�nter Blobel, who in a news conference given just after he was awarded the Nobel Prize in Medicine, said that the main problem one encounters in one's research is "when your grants and papers are rejected because some stupid reviewer rejected them for dogmatic adherence to old ideas." According to the New York Times (October 12, 1999, p. A29), these comments "drew thunderous applause from the hundreds of sympathetic colleagues and younger scientists in the auditorium."

"And if Annalen der Physik rejected a paper, for whatever reason, any professional German physicist had an alternative: Zeitschrift f�r Physik. This journal would publish any paper submitted by any member of the German Physical Society. This journal published quite a few worthless papers. But it also published quite a few great papers, among them Heisenberg's first paper on the Uncertainty Principle, a central idea in quantum mechanics. There was no way in which referees or editors could stop an idea from appearing in the professional journals. In illustration of this, the great Danish physicist Niels Bohr said, according to Abraham Pais (The Genius of Science, p. 307), that if a physicist has an idea that seems crazy and he hesitates to publish so that someone else publishes the idea first and gets the credit, he has no one to blame but himself. In other words, it never occurred to Bohr that referees or editors could stop the publication of a new idea."

Investigate the nature of science and see what you find.

0 of 3 people found the following review helpful.
Loved it then
By James Cavallo
I studied this book many years ago in graduate school. Loved it then; love it now.

2 of 6 people found the following review helpful.
good book
By catshadow
it's the 2nd edition, though i didn't find any difference between them. the new one is not expensive, why not own it?

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Jumat, 06 Desember 2013

[G977.Ebook] Free PDF Networks and Services: Carrier Ethernet, PBT, MPLS-TP, and VPLS, by Mehmet Toy

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Networks and Services: Carrier Ethernet, PBT, MPLS-TP, and VPLS, by Mehmet Toy

This book provides a comprehensive understanding of current and debated future networking technologies. It gives insight into building end-to-end networks and services with Carrier Ethernet, PBT, MPLS-TP, and VPLS while also shedding light on the pros and cons of these technologies for service providers and enterprise network owners.

Focusing on layer-2 networking and services, Networks and Services covers:

  • The basics of Ethernet such as protocol stack, bridges, switches, and hubs
  • Key techniques that are being used in building carrier-class Carrier Ethernet networks and services like synchronization, pseudowires, and protection
  • Carrier Ethernet network architectures and services that are currently deployed in the industry
  • Traffic management and OAM capabilities of Carrier Ethernet
  • Circuit Emulation Services
  • PBB and PBT to resolve possible scalability issues of Carrier Ethernet
  • Technologies that are competing or working with Carrier Ethernet in forming data networks and services, Transport MPLS, MPLS Transport Profile, and VPLS

Networks and Services: Carrier Ethernet, PBT, MPLS-TP, and VPLS is ideal for network architects, engineers, and planning professionals in telecommunications, as well as students and researchers in related disciplines.

  • Sales Rank: #984086 in Books
  • Brand: Brand: Wiley-Interscience
  • Published on: 2012-10-16
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.60" h x 1.10" w x 6.40" l, 1.58 pounds
  • Binding: Hardcover
  • 432 pages
Features
  • Used Book in Good Condition

About the Author

MEHMET TOY, PhD, is a Distinguished Engineer at Comcast and represents the company in the Metro Ethernet Forum (MEF) and IEEE standards. Previously, he held management and technical positions at ADVA Optical Networking, Intel Corporation, Verizon Wireless, Axiowave Networks, Fujitsu Network Communications, AT&T Bell Labs, and Lucent Technologies. Dr. Toy contributed to the research, development and standardization of various telecommunication technologies including IP Multimedia System (IMS), Asynchronous Transfer Mode (ATM), optical, IP/MPLS, and wireless. He has authored multiple books in these areas and various articles in data networking and signal processing, and has taught at universities as a tenure-track and adjunct faculty member.

Most helpful customer reviews

1 of 1 people found the following review helpful.
Highly Organized
By Telecom Eng
Highly organized writing that presents itself in an easy to read format. Mehmet presents difficult to explain topics with thoughts of conveying understanding.

0 of 0 people found the following review helpful.
A recommended book
By candan
Very helpful book on a subject not so much investigated. A good review of Carrier grade features of Ethernet.

0 of 0 people found the following review helpful.
Great Raed
By Brad Hutchins
Great read of the next big jump in MAN / WAN technologies after, or working with, router layer 2.5 MPLS

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Kamis, 05 Desember 2013

[C965.Ebook] Download Process Scale Purification of AntibodiesFrom Wiley

Download Process Scale Purification of AntibodiesFrom Wiley

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Process Scale Purification of AntibodiesFrom Wiley

Process Scale Purification of AntibodiesFrom Wiley



Process Scale Purification of AntibodiesFrom Wiley

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Process Scale Purification of AntibodiesFrom Wiley

Promoting a continued and much-needed renaissance in biopharmaceutical manufacturing, this book covers the different strategies and assembles top-tier technology experts to address the challenges of antibody purification.

•�� �Updates existing topics and adds new ones that include purification of antibodies produced in novel production systems, novel separation technologies, novel antibody formats and alternative scaffolds, and strategies for ton-scale manufacturing
•�� �Presents new and updated discussions of different purification technologies, focusing on how they can address the capacity crunch in antibody purification
•�� �Emphasizes antibodies and innovative chromatography methods for processing

  • Sales Rank: #1403035 in Books
  • Published on: 2017-04-03
  • Original language: English
  • Dimensions: 9.40" h x 1.60" w x 6.30" l,
  • Binding: Hardcover
  • 752 pages

From the Back Cover

Stay on the cutting edge of antibody purification with the insights of industry experts

Biopharmaceutical companies are under extreme pressure to develop robust and economical large-scale processes while consistently meeting regulatory standards for safety and purity. Unfortunately, while upstream productivity has increased in line with demand, downstream processing is mired in a technology crisis resulting in production bottlenecks. Antibody purification is sandwiched between fermentation and drug formulation, two areas that have traditionally received the lion's share of industry awareness as well as generous research funding and attention in the literature. As a result, improvements in purification technology are needed urgently to meet the challenges of increasing demands without sacrificing product quality.

The second edition of Process Scale Purification of Antibodies continues the legacy of its predecessor to offer scientists, researchers, and engineers an essential resource focused on best practices in manufacturing antibody drugs. It covers different antibody purification strategies, including new developments since the publication of the first edition, and an assembly of top-tier experts in these disparate technologies with the common aim of addressing problems in process-scale antibody purification.

Recognized for providing a fresh perspective on traditional chromatography as well as alternative technologies and unit operations, the first edition covered innovative developments in protein purification like smart membranes, bioaffinity mimetics as well as orthogonal, and integrated strategies. The revision updates these topics and also introduces platform concepts that have gained traction over the ensuing years—including the purification of antibodies produced in novel production systems, novel separation technologies, novel antibody formats and alternative scaffolds, and strategies for ton-scale manufacturing.

Process Scale Purification of Antibodies, therefore, consolidates the unique niche occupied by its predecessor and maintains interest in this neglected subject area by promoting the continued, much-needed renaissance in antibody purification.

About the Author

Uwe Gottschalk, PhD,is Chief Technology Officer at Lonza Pharma/Biotech, Switzerland. Previously, he served as Group Vice President at Sartorius Stedim Biotech (2004-2014) and in various development and manufacturing capacities at Bayer Health Care (1991–2004). Dr. Gottschalk received a doctorate in chemistry from the University of M�nster (Germany) for work on antibody-drug conjugates at the Cancer Research Campaign Laboratories in Nottingham (UK). He is Head Lecturer at the University of Duisburg-Essen, Germany, and has written extensively in the areas of industrial biotechnology and somatic gene therapy.

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